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cb2 antagonist 6 iodo 2 methyl 1  (Santa Cruz Biotechnology)


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    Santa Cruz Biotechnology cb2 antagonist 6 iodo 2 methyl 1
    Cb2 Antagonist 6 Iodo 2 Methyl 1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 92/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb2+antagonist+6+iodo+2+methyl+1/AM-630/pm39705234-202-14-19
    Average 92 stars, based on 7 article reviews
    cb2 antagonist 6 iodo 2 methyl 1 - by Bioz Stars, 2026-10
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    Article Title: Cannabis sativa extracts inhibit LDL oxidation and the formation of foam cells in vitro , acting as potential multi-step inhibitors of atherosclerosis development
    Article Snippet: The following cannabinoid receptor ligands were used: the CB1 antagonist 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide (AM251) and the CB2 antagonist 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone (AM630) (Santa Cruz Biotechnology), the TRPV-1 antagonist 2E-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide (AMG9810) (ABCAM), the TRPV-1 agonist 8-methyl-N-vanillyl-6-nonenamide or capsaicin (ABCAM), the GPR55 agonist 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl) benzenesulfonamide (ML184, Sigma-Aldrich), the GPR55 antagonist 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid (CID16020046), the TRPV4 antagonist 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N -[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide (HC067047) (Santa Cruz Biotech.), the TRPV4 agonist N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl) sulfonyl]amine]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]benzo [b]thiophene-2-carboxamide (GSK1016790A) (Santa Cruz Biotech.), the endocannabinoid and CB1 and CB2 agonist N-arachidonoylethanolamine or anandamide (AEA) (Santa Cruz Biotechnology).



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    Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg <t>AM630</t> + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.
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    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg <t>AM630</t> + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.
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    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg <t>AM630</t> + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.
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    Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Figure 7. Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p< 0.01.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 7. Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p< 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Figure 8. FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p< 0.01.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 8. FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p< 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques: Expressing

    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p < 0.01.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p < 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p < 0.01.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p < 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques: Expressing